Significant Other is a beautifully unconventional love story told through a comedic lens, the series explores the depths of love, disappointment, and the surprises that life still has to offer. Anna and Sam are two lonely neighbours in their mid-40's, who embark on a hesitant, obstacle-filled relationship after drastic life events bring them together. These are not your conventional soulmates; Anna, who has given up on love, is defensive and closed off, and Sam, a newly separated father-of-two, is reactive and emotionally vulnerable. But as this strange love story unfolds with wryly observed wit and warmth, could these deeply flawed individuals - both at a time in their lives when change is difficult and rarely expected - influence each other for the better?